abstract：:Biomechanical model based deformable image registration has been widely used to account for prostate deformation in various medical imaging procedures. Biomechanical material properties are important components of a biomechanical model. In this study, the effect of incorporating tumor-specific material properties in t...

journal_title：Physics in medicine and biology

authors： Samavati N,McGrath DM,Jewett MA,van der Kwast T,Ménard C,Brock KK

更新日期：2015-01-07 00:00:00

abstract：:This work presents a Monte Carlo model of Leksell Gamma Knife Perfexion as well as the main parameters of the dose distribution in the standard phantom obtained using this model. The model is developed in the Geant4 simulation toolkit in a modular way which enables its reuse in other Perfexion studies. Large phase spa...

journal_title：Physics in medicine and biology

authors： Pipek J,Novotný J,Novotný J,Kozubíková P

更新日期：2014-12-21 00:00:00

abstract：:Many applications in medical imaging include image registration for matching of images from the same or different modalities. In the case of full data sampling, the respective reconstructed images are usually of such a good image quality that standard deformable volume-to-volume (3D-3D) registration approaches can be ...

journal_title：Physics in medicine and biology

authors： Flach B,Brehm M,Sawall S,Kachelrieß M

更新日期：2014-12-21 00:00:00

abstract：:Proton CT nowadays aims at improving hadron therapy treatment planning by mapping the stopping power of materials. In order to optimize a spatial resolution of the reconstructed images, the most likely path (MLP) of each proton can be computed. We investigated the errors in the computation of this path due to the conf...

journal_title：Physics in medicine and biology

authors： Bopp C,Rescigno R,Rousseau M,Brasse D

更新日期：2014-12-07 00:00:00

abstract：:A parametric model for the x-ray linear attenuation coefficient is used to describe the compositional dependence of Hounsfield numbers measured by medical CT scanners. Measurements with materials of known density and composition, that span and evenly sample the compositional range of tissues, are written as linear sim...

journal_title：Physics in medicine and biology

authors： Midgley SM

更新日期：2014-12-07 00:00:00

abstract：:A Monte Carlo model of a novel electronic portal imaging device (EPID) has been developed using Geant4 and its performance for imaging and dosimetry applications in radiotherapy has been characterised. The EPID geometry is based on a physical prototype under ongoing investigation and comprises an array of plastic scin...

journal_title：Physics in medicine and biology

authors： Blake SJ,McNamara AL,Vial P,Holloway L,Kuncic Z

更新日期：2014-11-21 00:00:00

abstract：:An efficient registration strategy is described that aims to help solve delicate medical imaging registration problems. It consists of running several registration methods for each dataset and selecting the best one for each specific dataset, according to an evaluation criterion. Finally, the quality of the registrati...

journal_title：Physics in medicine and biology

authors： Tacchella JM,Roullot E,Lefort M,Cohen ME,Guillevin R,Petrirena G,Delattre JY,Habert MO,Yeni N,Kas A,Frouin F

更新日期：2014-11-21 00:00:00

abstract：:Focused ultrasound and microbubbles have been extensively used to generate therapeutic bioeffects. Despite encouraging in vivo results, there remains poor control of the magnitude and spatial distribution of these bioeffects due to the limited ability of conventional pulse shapes and sequences to control cavitation dy...

journal_title：Physics in medicine and biology

authors： Pouliopoulos AN,Bonaccorsi S,Choi JJ

更新日期：2014-11-21 00:00:00

abstract：:An overview of the theory of 4D image reconstruction for emission tomography is given along with a review of the current state of the art, covering both positron emission tomography and single photon emission computed tomography (SPECT). By viewing 4D image reconstruction as a matter of either linear or non-linear par...

journal_title：Physics in medicine and biology

authors： Reader AJ,Verhaeghe J

更新日期：2014-11-21 00:00:00

abstract：:Exploiting the field response of magnetic tracers, magnetic particle imaging (MPI) allows direct, local quantification of the tracer concentration in bulk structures. Here, we investigated the use of characteristic field response functions to spatially resolve the absolute concentration of multiple nanoparticle specie...

journal_title：Physics in medicine and biology

authors： Han SH,Cho E,Lee DK,Cho G,Kim YR,Cho H

更新日期：2014-11-07 00:00:00

abstract：:A reader study was conducted to tune the parameters of an observer model used to predict the detectability index (dʹ ) of test objects as a task-based quality control (QC) metric for digital mammography. A simple test phantom was imaged to measure the model parameters, namely, noise power spectrum,modulation transfer ...

journal_title：Physics in medicine and biology

authors： Bloomquist AK,Mainprize JG,Mawdsley GE,Yaffe MJ

更新日期：2014-11-07 00:00:00

abstract：:Monte Carlo simulations were used to investigate large-angle x-ray scatter at design energy of 25 keV during small field of view (9.6 cm × 5 cm) differential phase contrast imaging of the breast using Talbot-Lau interferometry. Homogenous, adipose and fibroglandular breasts of uniform thickness ranging from 2 to 8 cm ...

journal_title：Physics in medicine and biology

authors： Vedantham S,Shi L,Karellas A

更新日期：2014-11-07 00:00:00

abstract：:Prenatal events such as intrauterine growth restriction and increased cardiovascular risk in later life have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. In order to assess and manage atherosclerosis and cardiovascular disease risk in adults and child...

journal_title：Physics in medicine and biology

authors： Veronese E,Tarroni G,Visentin S,Cosmi E,Linguraru MG,Grisan E

更新日期：2014-11-07 00:00:00

abstract：:Maximum likelihood estimation (MLE) is presented as a statistical tool to evaluate the contribution of measurement error to any measurement series where the same quantity is measured using different independent methods. The technique was tested against artificial data sets; generated for values of underlying variation...

journal_title：Physics in medicine and biology

authors： Sage JP,Mayles WP,Mayles HM,Syndikus I

更新日期：2014-10-21 00:00:00

abstract：:Doxorubicin (Dox) is a well-established chemotherapeutic agent, however it has limited efficacy in treating brain malignancies due to the presence of the blood-brain barrier (BBB). Recent preclinical studies have demonstrated that focused ultrasound induced BBB disruption (BBBD) enables efficient delivery of Dox to th...

journal_title：Physics in medicine and biology

authors： Nhan T,Burgess A,Lilge L,Hynynen K

更新日期：2014-10-21 00:00:00

abstract：:The enormous advances in the understanding of human anatomy, physiology and pathology in recent decades have led to ever-improving methods of disease prevention, diagnosis and treatment. Many of these achievements have been enabled, at least in part, by advances in ionizing radiation detectors. Radiology has been tran...

journal_title：Physics in medicine and biology

authors： Seco J,Clasie B,Partridge M

更新日期：2014-10-21 00:00:00

abstract：:With the addition of variable bed speed capabilities, continuous bed motion (CBM) becomes an acquisition generalization for axial sensitivity modeling and therefore a flexible tool in axial local image quality adjustment. In this paper, we describe the principles behind CBM mode planning and its influence on image rec...

journal_title：Physics in medicine and biology

authors： Panin VY,Smith AM,Hu J,Kehren F,Casey ME

更新日期：2014-10-21 00:00:00

abstract：:Estimation of a set of parameters that describe the geometry of the cone-beam computed tomography system plays an important role in the geometrical calibration. In the calibration process, the helical phantom consisting of spherical markers arranged on a helical trajectory has been widely applied. To directly determin...

journal_title：Physics in medicine and biology

authors： Xu M,Zhang C,Liu X,Li D

更新日期：2014-10-07 00:00:00

abstract：:The purpose of this study was to derive a complete set of correction and perturbation factors for output factors (OF) and dose profiles. Modern small field detectors were investigated including a plastic scintillator (Exradin W1, SI), a liquid ionization chamber (microLion 31018, PTW), an unshielded diode (Exradin D1V...

journal_title：Physics in medicine and biology

authors： Papaconstadopoulos P,Tessier F,Seuntjens J

更新日期：2014-10-07 00:00:00

abstract：:4D cone beam computed tomography (4DCBCT) is an emerging image guidance strategy used in radiotherapy where projections acquired during a scan are sorted into respiratory bins based on the respiratory phase or displacement. 4DCBCT reduces the motion blur caused by respiratory motion but increases streaking artefacts d...

journal_title：Physics in medicine and biology

authors： O'Brien RT,Kipritidis J,Shieh CC,Keall PJ

更新日期：2014-10-07 00:00:00

abstract：:Radiation dose calculation using models of the human anatomy has been a subject of great interest to radiation protection, medical imaging, and radiotherapy. However, early pioneers of this field did not foresee the exponential growth of research activity as observed today. This review article walks the reader through...

journal_title：Physics in medicine and biology

authors： Xu XG

更新日期：2014-09-21 00:00:00

abstract：:ICRP Publication 116 on 'Conversion coefficients for radiological protection quantities for external radiation exposures', provides fluence-to-dose conversion coefficients for organ-absorbed doses and effective dose for various types of external exposures (ICRP 2010 ICRP Publication 116). The publication supersedes th...

journal_title：Physics in medicine and biology

authors： Petoussi-Henss N,Bolch WE,Eckerman KF,Endo A,Hertel N,Hunt J,Menzel HG,Pelliccioni M,Schlattl H,Zankl M

更新日期：2014-09-21 00:00:00

abstract：:In the IAEA-AAPM dosimetry formalism, detector measurements in general nonstandard conditions are corrected using the factor k(f(clin),f(msr))(Q(clin),Q(msr)). This factor needs to be evaluated on a case-by-case basis which is difficult to accomplish in practice. The present paper aims to provide a method that allows ...

journal_title：Physics in medicine and biology

authors： Kamio Y,Bouchard H

更新日期：2014-09-07 00:00:00

abstract：:Magnetic Resonance Electrical Impedance Tomography (MREIT) is an MRI method that enables mapping of internal conductivity and/or current density via measurements of magnetic flux density signals. The MREIT measures only the z-component of the induced magnetic flux density B = (Bx, By, Bz) by external current injection...

journal_title：Physics in medicine and biology

authors： Jeong WC,Chauhan M,Sajib SZ,Kim HJ,Serša I,Kwon OI,Woo EJ

更新日期：2014-09-07 00:00:00

abstract：:The first goal of this paper is to clarify the reference conditions for the reference dosimetry of clinical proton beams. A clear distinction is made between proton beam delivery systems which should be calibrated with a spread-out Bragg peak field and those that should be calibrated with a (pseudo-)monoenergetic prot...

journal_title：Physics in medicine and biology

authors： Gomà C,Lorentini S,Meer D,Safai S

更新日期：2014-09-07 00:00:00

abstract：:It is a challenging problem to resolve and identify drug (or non-specific fluorophore) distribution throughout the whole body of small animals in vivo. In this article, an algorithm of unmixing multispectral fluorescence tomography (MFT) images based on independent component analysis (ICA) is proposed to solve this pr...

journal_title：Physics in medicine and biology

authors： Pu H,Zhang G,He W,Liu F,Guang H,Zhang Y,Bai J,Luo J

更新日期：2014-09-07 00:00:00

abstract：:Numerous studies have reported the measurements of the dielectric properties of the skin. Clarifying the manner in which the human body interacts with electromagnetic waves is essential for medical research and development, as well as for the safety assessment of electromagnetic wave exposure. The skin comprises sever...

journal_title：Physics in medicine and biology

authors： Sasaki K,Wake K,Watanabe S

更新日期：2014-08-21 00:00:00

abstract：:Coronary computed tomography angiography (cCTA) is a commonly used imaging modality for the evaluation of coronary artery disease. cCTA is generally reconstructed in multiple cardiac phases because different coronary arteries may be better visualized in some phases than in others due to the periodic cardiac motion. We...

journal_title：Physics in medicine and biology

authors： Hadjiiski L,Zhou C,Chan HP,Chughtai A,Agarwal P,Kuriakose J,Kazerooni E,Wei J,Patel S

更新日期：2014-08-21 00:00:00

abstract：:Determining accurate in vivo dosimetry in brachytherapy treatment with high dose gradients is challenging. Here we introduce, investigate, and characterize a novel in vivo dosimeter and readout technique with the potential to address this problem. A cylindrical (4 mm × 20 mm) tissue equivalent radiochromic dosimeter P...

journal_title：Physics in medicine and biology

authors： Vidovic AK,Juang T,Meltsner S,Adamovics J,Chino J,Steffey B,Craciunescu O,Oldham M

更新日期：2014-07-21 00:00:00

abstract：:The aim of this study was to measure entrance skin doses on patients undergoing cone-beam computed tomography (CBCT) examinations, to establish conversion factors between skin and organ doses, and to estimate cancer risk from CBCT exposures. 266 patients (age 8-83) were included, involving three imaging centres. CBCT ...

journal_title：Physics in medicine and biology

authors： Pauwels R,Cockmartin L,Ivanauskaité D,Urbonienė A,Gavala S,Donta C,Tsiklakis K,Jacobs R,Bosmans H,Bogaerts R,Horner K,SEDENTEXCT Project Consortium.

更新日期：2014-07-21 00:00:00

abstract：:Although physical metrics can objectively characterize computed tomography (CT) image quality, quantitative approaches to predict human observer performance are more accurate and clinically relevant. This study compared a modified channelized Hotelling model observer (CHO) with human observers in a shape discriminatio...

journal_title：Physics in medicine and biology

authors： Zhang Y,Leng S,Yu L,Carter RE,McCollough CH

更新日期：2014-07-07 00:00:00

abstract：:Sparse-view CT reconstruction algorithms via total variation (TV) optimize the data iteratively on the basis of a noise- and artifact-reducing model, resulting in significant radiation dose reduction while maintaining image quality. However, the piecewise constant assumption of TV minimization often leads to the appea...

journal_title：Physics in medicine and biology

authors： Niu S,Gao Y,Bian Z,Huang J,Chen W,Yu G,Liang Z,Ma J

更新日期：2014-06-21 00:00:00

abstract：:Simultaneous dual-radionuclide myocardial perfusion/innervation SPECT imaging can provide important information about the mismatch between scar tissue and denervated regions. The Siemens IQ-SPECT system developed for cardiac imaging uses a multifocal SMARTZOOM collimator to achieve a four-fold sensitivity for the card...

journal_title：Physics in medicine and biology

authors： Du Y,Bhattacharya M,Frey EC

更新日期：2014-06-07 00:00:00

abstract：:The use of liquid ionization chambers in radiotherapy has grown during the past few years. While for air ionization chambers the k(TP) correction for air mass density due to pressure and temperature variations is well known, less work has been done on the case of liquid ionization chambers, where there is still the ne...

journal_title：Physics in medicine and biology

authors： Gómez F,González-Castaño D,Díaz-Botana P,Pardo-Montero J

更新日期：2014-06-07 00:00:00

abstract：:Despite the early recognition of the potential of proton imaging to assist proton therapy (Cormack 1963 J. Appl. Phys. 34 2722), the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography applications such as computed tomography (CT), the water-equival...

journal_title：Physics in medicine and biology

authors： Poludniowski G,Allinson NM,Anaxagoras T,Esposito M,Green S,Manolopoulos S,Nieto-Camero J,Parker DJ,Price T,Evans PM

更新日期：2014-06-07 00:00:00

abstract：:This paper introduces a novel compartmental model describing the excretion of 18F-fluoro-deoxyglucose (FDG) in the renal system and a numerical method based on the maximum likelihood for its reduction. This approach accounts for variations in FDG concentration due to water re-absorption in renal tubules and the increa...

journal_title：Physics in medicine and biology

authors： Garbarino S,Caviglia G,Sambuceti G,Benvenuto F,Piana M

更新日期：2014-05-21 00:00:00

abstract：:Clinical studies have established a strong benefit from adjuvant mild hyperthermia (HT) to radio- and chemotherapy for many tumor sites, including the head and neck (H&N). The recently developed HYPERcollar allows the application of local radiofrequency HT to tumors in the entire H&N. Treatment quality is optimized us...

journal_title：Physics in medicine and biology

authors： Paulides MM,Bakker JF,Hofstetter LW,Numan WC,Pellicer R,Fiveland EW,Tarasek M,Houston GC,van Rhoon GC,Yeo DT,Kotek G

更新日期：2014-05-07 00:00:00

abstract：:The UK, European and IAEA protocols for breast dosimetry in mammography use tabulations of conversion factors, which relate measurements of incident air kerma to the mean glandular dose to the breast. To supplement the existing tabulations, a Monte Carlo computer program has been used to calculate conversion factors f...

journal_title：Physics in medicine and biology

authors： Dance DR,Young KC

更新日期：2014-05-07 00:00:00

abstract：:This work investigated the differences between multileaf collimator (MLC) positioning accuracy determined using either log files or electronic portal imaging devices (EPID) and then assessed the possibility of reducing patient specific quality control (QC) via phantom-less methodologies. In-house software was develope...

journal_title：Physics in medicine and biology

authors： Agnew A,Agnew CE,Grattan MW,Hounsell AR,McGarry CK

更新日期：2014-05-07 00:00:00

abstract：:The purpose of this study was to examine the use of three physical image quality metrics in the calibration of an automatic exposure control (AEC) device for chest radiography with a computed radiography (CR) imaging system. The metrics assessed were signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and mean ...

journal_title：Physics in medicine and biology

authors： Moore CS,Wood TJ,Avery G,Balcam S,Needler L,Beavis AW,Saunderson JR

更新日期：2014-05-07 00:00:00